PRKAR1B · rs11545042
Where this position leads
Condition: Hidradenitis Suppurativa
What the study found
Who was studied 2,864 European ancestry cases, 1,315,903 European ancestry controls, 1,077 African ancestry cases, 119,700 African ancestry controls.
The effect Each copy of the G allele carried 1.19 times the odds of Hidradenitis suppurativa (95% confidence interval 1.12-1.27); p = 3 × 10−8.
How common The G allele had a frequency of about 16% in the people studied.
Where it sits Chromosome 7, band 7p22.3 — a synonymous change in PRKAR1B.
What ClinVar records
Classification
Benign for PRKAR1B-related disorder; criteria provided, single submitter (1 of 4 stars, 4 submitters), last evaluated 2022-03-24.
ClinVar record 1210100 NM_001164760.2(PRKAR1B):c.1014T>C (p.Thr338=)
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs11545042 is a single position in the genome, in or near the PRKAR1B gene. Published research associates it with hidradenitis suppurativa. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Hidradenitis Suppurativa. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, The Journal of investigative dermatology 2026, PMID:41548865. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hidradenitis suppurativa (rs11545042). MyGeneLog™. https://www.mygenelog.com/variants/rs11545042