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Who was studied 2,478 European ancestry cases, 979 ancestry controls both from the same 1,070 families.
The effect
Each copy of the A allele shifted the measure 6.03 lower (95% confidence interval -); p = 2 × 10−9.
Where it sits Chromosome 2, band 2p16.1 — in an intron of REL-DT.
What each result means
A/ATwo copies of the version the research linked to Alzheimer disease and age of onset. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer disease and age of onset. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer disease and age of onset. This is the starting point the study compared everyone against.
Molecular psychiatry · 2016 · PMID 26830138 · open access
Questions about rs115291397
What is rs115291397?
rs115291397 is a single position in the genome, in or near the near PAPOLG gene. Published research associates it with alzheimer disease and age of onset. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs115291397 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs115291397 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs115291397 come from?
GWAS Catalog, Mol Psychiatry 2016, PMID:26830138. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 41225322124Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity0Meta AI5Microsoft · Copilot3Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others24Total41Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer disease and age of onset (rs115291397). MyGeneLog™. https://www.mygenelog.com/variants/rs115291397