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Who was studied 17,101 European ancestry cases, 721,947 European ancestry controls.
The effect
Each copy of the T allele carried 1.33 times the odds of Kidney stone disease (95% confidence interval 1.27-1.4); p = 2 × 10−32.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 1, band 1p36.12 — between genes, 9.4 kb from ALPL.
What each result means
C/CNo copy of the version the research linked to Kidney stone disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Kidney stone disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Kidney stone disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of the American Society of Nephrology : JASN · 2023 · PMID 37787550 · open access
Questions about rs115239632
What is rs115239632?
rs115239632 is a single position in the genome, in or near the near ALPL gene. Published research associates it with kidney stone disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs115239632 linked to?
On MyGeneLog this position is linked to Urolithiasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs115239632 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs115239632 come from?
GWAS Catalog, Journal of the American Society of Nephrology : JASN 2023, PMID:37787550. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 122316Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others6Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Kidney stone disease (rs115239632). MyGeneLog™. https://www.mygenelog.com/variants/rs115239632