Standard

Opioid overdose severity score

MCOLN1 · rs115208233

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Opioid overdose severity score — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Opioid overdose severity score.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Opioid overdose severity score compared to the general population.

Source

Genome-wide scan identifies opioid overdose risk locus close to MCOLN1

Cheng Z, Yang BZ, Zhou H, Nunez Y, Kranzler HR, Gelernter J

Addiction biology · 2020 · PMID 31362332

Questions about rs115208233

What is rs115208233?

rs115208233 is a single position in the genome, in or near the MCOLN1 gene. Published research associates it with opioid overdose severity score. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs115208233 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115208233 come from?

GWAS Catalog, Addict Biol 2019, PMID:31362332. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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