Sensitive

End-stage renal disease in Type 1 diabetics

LINC01266 · rs115061173

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,187 European ancestry cases, 12,101 European ancestry controls.

The effect Each copy of the A allele carried 9.40 times the odds of End-stage renal disease in Type 1 diabetics; p = 4 × 10⁻⁸.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 3, band 3p26.3 — between genes, 14.6 kb from LINC01266.

What each result means

A/A Two copies of the version the research linked to End-stage renal disease in Type 1 diabetics. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to End-stage renal disease in Type 1 diabetics. That is a smaller link than two copies.

T/T No copy of the version the research linked to End-stage renal disease in Type 1 diabetics. This is the starting point the study compared everyone against.

Source

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C

and 76 more — show all

Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E, Doyle R, Ahluwalia TS, Lajer M, Hughes MF, Park J, Skupien J, Spiliopoulou A, Liu A, Menon R, Boustany-Kari CM, Kang HM, Nelson RG, Klein R, Klein BE, Lee KE, Gao X, Mauer M, Maestroni S, Caramori ML, de Boer IH, Miller RG, Guo J, Boright AP, Tregouet D, Gyorgy B, Snell-Bergeon JK, Maahs DM, Bull SB, Canty AJ, Palmer CNA, Stechemesser L, Paulweber B, Weitgasser R, Sokolovska J, Rovīte V, Pīrāgs V, Prakapiene E, Radzeviciene L, Verkauskiene R, Panduru NM, Groop LC, McCarthy MI, Gu HF, Möllsten A, Falhammar H, Brismar K, Martin F, Rossing P, Costacou T, Zerbini G, Marre M, Hadjadj S, McKnight AJ, Forsblom C, McKay G, Godson C, Maxwell AP, Kretzler M, Susztak K, Colhoun HM, Krolewski A, Paterson AD, Groop PH, Rich SS, Hirschhorn JN, Florez JC

SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium

Journal of the American Society of Nephrology : JASN · 2019 · PMID 31537649

Questions about rs115061173

What is rs115061173?

rs115061173 is a single position in the genome, in or near the LINC01266 gene. Published research associates it with end-stage renal disease in type 1 diabetics. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs115061173 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115061173 come from?

GWAS Catalog, Journal of the American Society of Nephrology : JASN 2019, PMID:31537649. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

End-stage renal disease in Type 1 diabetics (rs115061173). MyGeneLog™. https://www.mygenelog.com/variants/rs115061173

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