A/APublished research associates this genotype with typical/baseline likelihood of Osteoarthritis — no copies of the reported risk allele.
A/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Osteoarthritis.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Osteoarthritis compared to the general population.
Nature genetics · 2019 · PMID 30664745 · open access
Questions about rs1149620
What is rs1149620?
rs1149620 is a single position in the genome, in or near the TSKU gene. Published research associates it with osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1149620 linked to?
On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs1149620 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1149620 come from?
GWAS Catalog, Nat Genet 2019, PMID:30664745. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.