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Glypican-5 levels

GPC5 · rs114910989

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻³⁴, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 10,708 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.668 higher (95% confidence interval 0.56-0.77); p = 5 × 10⁻³⁵.

How common The T allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 13, band 13q31.3 — in an intron of GPC5.

What each result means

G/G No copy of the version the research linked to Glypican-5 levels. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Glypican-5 levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Glypican-5 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Mapping the proteo-genomic convergence of human diseases

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J, Stewart ID, Kerrison ND, Luan J, Raffler J

and 9 more — show all

Arnold M, Arlt W, O'Rahilly S, Kastenmüller G, Gamazon ER, Hingorani AD, Scott RA, Wareham NJ, Langenberg C

Science (New York, N.Y.) · 2021 · PMID 34648354

Questions about rs114910989

What is rs114910989?

rs114910989 is a single position in the genome, in or near the GPC5 gene. Published research associates it with glypican-5 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs114910989 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114910989 come from?

GWAS Catalog, Science (New York, N.Y.) 2021, PMID:34648354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glypican-5 levels (rs114910989). MyGeneLog™. https://www.mygenelog.com/variants/rs114910989

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