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Childhood obesity

CMKLR2 · rs114670539

Where this position leads

Condition: Obesity and Body Weight

rs114670539 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs114670539 rs114670539 CMKLR2

What the study found

Who was studied 8,613 European ancestry cases, 3,213 African American cases, 69 Moroccan ancestry cases, 986 Hispanic/Latino cases, 124 East Asian ancestry cases, 12,696 European ancestry controls, 1,392 African American controls, 64 Moroccan ancestry controls, 993 Hispanic/Latino controls, 454 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.27 higher (95% confidence interval 0.17-0.37); p = 5 × 10−8.

Where it sits Chromosome 2, band 2q33.3 — in an intron of CMKLR2.

What each result means

C/C No copy of the version the research linked to Childhood obesity. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Childhood obesity. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Childhood obesity. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs114670539

What is rs114670539?

rs114670539 is a single position in the genome, in or near the CMKLR2 gene. Published research associates it with childhood obesity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114670539 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs114670539 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114670539 come from?

GWAS Catalog, Hum Mol Genet 2019, PMID:31504550. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Childhood obesity (rs114670539). MyGeneLog™. https://www.mygenelog.com/variants/rs114670539

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