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Depressive symptoms (MTAG)

near CCDC68 · rs114658852

Where this position leads

Condition: Depression (Self-Reported Symptoms)

rs114658852 Condition: Depression (Self-Reported Symptoms) Depression (Self-Reported Symptoms) Condition rs114658852 rs114658852 near CCDC68

What the study found

Who was studied 354,862 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0239 higher (95% confidence interval 0.017-0.031); p = 3 × 10−11.

How common The C allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 18, band 18q21.2 — between genes, 1.9 kb from LINC03035.

What each result means

C/C Two copies of the version the research linked to Depressive symptoms (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Depressive symptoms (MTAG). That is a smaller link than two copies.
T/T No copy of the version the research linked to Depressive symptoms (MTAG). This is the starting point the study compared everyone against.
Source

Questions about rs114658852

What is rs114658852?

rs114658852 is a single position in the genome, in or near the near CCDC68 gene. Published research associates it with depressive symptoms (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114658852 linked to?

On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.

Does having rs114658852 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114658852 come from?

GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depressive symptoms (MTAG) (rs114658852). MyGeneLog™. https://www.mygenelog.com/variants/rs114658852

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