Sensitive

Schizophrenia

HLA-X · rs114618162

Where this position leads

Condition: Schizophrenia

rs114618162 Condition: Schizophrenia Schizophrenia Condition rs114618162 rs114618162 HLA-X

What the study found

Who was studied 14,023 East Asian ancestry cases, 33,640 European ancestry cases, 31,505 East Asian ancestry controls, 43,456 European ancestry controls.

The effect Each copy of the G allele carried 1.13 times the odds of Schizophrenia (95% confidence interval 1.1-1.15); p = 6 × 10−16.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of LINC01149.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population.
Source

Questions about rs114618162

What is rs114618162?

rs114618162 is a single position in the genome, in or near the HLA-X gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114618162 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs114618162 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114618162 come from?

GWAS Catalog, Schizophr Bull 2018, PMID:30285260. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Schizophrenia (rs114618162). MyGeneLog™. https://www.mygenelog.com/variants/rs114618162

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