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Leprosy

HLA-C · rs114598080

Where this position leads

Condition: Leprosy

rs114598080 Condition: Leprosy Leprosy Condition rs114598080 rs114598080 HLA-C

What the study found

Who was studied 1,749 Vietnamese ancestry cases; replicated in 1,181 Vietnamese ancestry cases, 688 Vietnamese ancestry controls.

The effect Each copy of the A allele carried 1.47 times the odds of Leprosy (95% confidence interval 1.46-1.48); p = 9 × 10−13.

How common The A allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of WASF5P.

What each result means

A/A Two copies of the version the research linked to Leprosy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Leprosy. That is a smaller link than two copies.
G/G No copy of the version the research linked to Leprosy. This is the starting point the study compared everyone against.
Source

Questions about rs114598080

What is rs114598080?

rs114598080 is a single position in the genome, in or near the HLA-C gene. Published research associates it with leprosy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114598080 linked to?

On MyGeneLog this position is linked to Leprosy. The research behind each link, and its sources, are set out on that condition page.

Does having rs114598080 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114598080 come from?

GWAS Catalog, PLoS pathogens 2020, PMID:32421744. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Leprosy (rs114598080). MyGeneLog™. https://www.mygenelog.com/variants/rs114598080

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