Gene Knowledge Graph
UTC
Sensitive

Ovarian cancer-related tumor marker CA 125 levels

MSLNL · rs114590746

Where this position leads

Condition: Ovarian Cancer

rs114590746 Condition: Ovarian Cancer Ovarian Cancer Condition rs114590746 rs114590746 MSLNL

What the study found

Who was studied 21,758 European ancestry individuals; replicated in 9,173 individuals.

The effect Each copy of the T allele shifted the measure 1.04 lower; p = 5 × 10−48.

How common The T allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 16, band 16p13.3 — in an intron of MSLNL.

What each result means

C/C No copy of the version the research linked to Ovarian cancer-related tumor marker CA 125 levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Ovarian cancer-related tumor marker CA 125 levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Ovarian cancer-related tumor marker CA 125 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE
and 71 more — show all
Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A
Nature metabolism · 2020 · PMID 33067605

Questions about rs114590746

What is rs114590746?

rs114590746 is a single position in the genome, in or near the MSLNL gene. Published research associates it with ovarian cancer-related tumor marker ca 125 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114590746 linked to?

On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs114590746 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114590746 come from?

GWAS Catalog, Nature metabolism 2020, PMID:33067605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ovarian cancer-related tumor marker CA 125 levels (rs114590746). MyGeneLog™. https://www.mygenelog.com/variants/rs114590746

← See all variants