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C-reactive protein levels

near DUSP23 · rs114530473

Where this position leads

Condition: C-Reactive Protein Levels

rs114530473 Condition: C-Reactive Protein Levels C-Reactive Protein Levels Condition rs114530473 rs114530473 near DUSP23

What the study found

Who was studied 341,805 European ancestry individuals, 6,006 African ancestry individuals, 7,316 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.103 higher (95% confidence interval 0.088-0.119); p = 2 × 10−38.

Where it sits Chromosome 1, band 1q23.2 — between genes, 26.9 kb from DUSP23.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of C-reactive protein levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with C-reactive protein levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of C-reactive protein levels compared to the general population.
Source
Genetics of 35 blood and urine biomarkers in the UK Biobank
Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP
and 11 more — show all
Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA
FinnGen
Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs114530473

What is rs114530473?

rs114530473 is a single position in the genome, in or near the near DUSP23 gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114530473 linked to?

On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs114530473 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114530473 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

C-reactive protein levels (rs114530473). MyGeneLog™. https://www.mygenelog.com/variants/rs114530473

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