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Cortical surface area

near ARB2A · rs114489117

What the study found

Who was studied 33,992 European ancestry individuals; replicated in 14,727 European ancestry individuals, 2,943 individuals.

The effect Each copy of the A allele shifted the measure 31.7 lower (95% confidence interval 22.29-41.03); p = 4 × 10−11.

How common The A allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 5, band 5q15 — between genes, 2.7 kb from ARB2A.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cortical surface area compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cortical surface area.
T/T Published research associates this genotype with typical/baseline likelihood of Cortical surface area — no copies of the reported risk allele.
Source

Questions about rs114489117

What is rs114489117?

rs114489117 is a single position in the genome, in or near the near ARB2A gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs114489117 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114489117 come from?

GWAS Catalog, Science (New York, N.Y.) 2020, PMID:32193296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cortical surface area (rs114489117). MyGeneLog™. https://www.mygenelog.com/variants/rs114489117

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