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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 340,567 European ancestry individuals, 5,974 African ancestry individuals, 7,283 South Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0632 higher (95% confidence interval 0.044-0.082); p = 4 × 10−11.
Where it sits Chromosome 5, band 5p12 — in an intron of GHR.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Insulin-like growth factor 1 levels compared to the general population.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Insulin-like growth factor 1 levels.
C/CPublished research associates this genotype with typical/baseline likelihood of Insulin-like growth factor 1 levels — no copies of the reported risk allele.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs114437310
What is rs114437310?
rs114437310 is a single position in the genome, in or near the GHR gene. Published research associates it with insulin-like growth factor 1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs114437310 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs114437310 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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