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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 25,890 European ancestry cases, 743,585 European ancestry controls, 897 African American or Afro-Caribbean cases, 3,109 African American or Afro-Caribbean controls, 1,612 Hispanic or Latin American cases, 2,180 Hispanic or Latin American controls, 621 East Asian ancestry cases, 86,796 East Asian ancestry controls.
The effect
Each copy of the T allele carried 1.30 times the odds of Kidney cancer (95% confidence interval 1.2-1.42); p = 1 × 10−10.
How common The T allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 3, band 3q11.2 — between genes, 3.2 kb from NSUN3.
What each result means
C/CNo copy of the version the research linked to Kidney cancer. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Kidney cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Kidney cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs114427493 is a single position in the genome, in or near the near NSUN3 gene. Published research associates it with kidney cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs114427493 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs114427493 come from?
GWAS Catalog, Nature genetics 2024, PMID:38671320. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Kidney cancer (rs114427493). MyGeneLog™. https://www.mygenelog.com/variants/rs114427493