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Who was studied 46,802 European ancestry cases, 347,481 European ancestry controls; replicated in 23,948 European and unknown ancestry cases, 118,538 European and unknown ancestry controls.
The effect
Each copy of the A allele carried 1.16 times the odds of Asthma (95% confidence interval 1.11-1.2); p = 2 × 10−10.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — in an intron of HCG15.
What each result means
A/ATwo copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Asthma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
The European respiratory journal · 2019 · PMID 31619474
Questions about rs114357009
What is rs114357009?
rs114357009 is a single position in the genome, in or near the C6orf100 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs114357009 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs114357009 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs114357009 come from?
GWAS Catalog, The European respiratory journal 2019, PMID:31619474. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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