ADGRL3 · rs114355846
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 32 cases from twins, 487 controls from twins.
The effect Each copy of the T allele carried 4.65 times the odds of Revision surgery after total knee arthroplasty (95% confidence interval 2.78-7.79); p = 5 × 10−9.
How common The T allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 4, band 4q13.1 — in an intron of ADGRL3.
rs114355846 is a single position in the genome, in or near the ADGRL3 gene. Published research associates it with revision surgery after total knee arthroplasty. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, The Journal of bone and joint surgery. American volume 2022, PMID:34982741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Revision surgery after total knee arthroplasty (rs114355846). MyGeneLog™. https://www.mygenelog.com/variants/rs114355846