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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 95,184 European ancestry males, 27,521 African American or Afro-Caribbean males, 13,443 Admixed American ancestry males, 1,836 East Asian ancestry males.
The effect
Each copy of the G allele shifted the measure 0.115 lower (95% confidence interval 0.077-0.153); p = 3 × 10−9.
Where it sits Chromosome 4, band 4p16.3 — a missense change in HGFAC.
What each result means
A/ANo copy of the version the research linked to Total testosterone levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Total testosterone levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Total testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40316537 · open access
Questions about rs114303452
What is rs114303452?
rs114303452 is a single position in the genome, in or near the HGFAC gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs114303452 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs114303452 come from?
GWAS Catalog, Nature communications 2025, PMID:40316537. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total testosterone levels (rs114303452). MyGeneLog™. https://www.mygenelog.com/variants/rs114303452