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Sum eosinophil basophil counts

JAK1 · rs114269697

Where this position leads

Condition: Blood Cell Counts

rs114269697 Condition: Blood Cell Counts Blood Cell Counts Condition rs114269697 rs114269697 JAK1

What the study found

Who was studied 171,771 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.105 lower (95% confidence interval 0.074-0.136); p = 3 × 10−11.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 1, band 1p31.3 — in an intron of JAK1.

What each result means

A/A Two copies of the version the research linked to Sum eosinophil basophil counts. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Sum eosinophil basophil counts. That is a smaller link than two copies.
C/C No copy of the version the research linked to Sum eosinophil basophil counts. This is the starting point the study compared everyone against.
Source

Questions about rs114269697

What is rs114269697?

rs114269697 is a single position in the genome, in or near the JAK1 gene. Published research associates it with sum eosinophil basophil counts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114269697 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs114269697 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114269697 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sum eosinophil basophil counts (rs114269697). MyGeneLog™. https://www.mygenelog.com/variants/rs114269697

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