Standard

Leprosy

near NTNG1 · rs114231265

Where this position leads

Condition: Leprosy

rs114231265 Condition: Leprosy Leprosy Condition rs114231265 rs114231265 near NTNG1

What the study found

Who was studied 284 Sub-Saharan African ancestry cases, 328 Sub-Saharan African ancestry controls.

The effect Each copy of the A allele carried 0.25 times the odds of Leprosy (95% confidence interval 0.14-0.44); p = 4 × 10−8.

Where it sits Chromosome 1, band 1p13.3 — between genes, 4.7 kb from NTNG1.

What each result means

A/A Two copies of the version the research linked to Leprosy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Leprosy. That is a smaller link than two copies.
G/G No copy of the version the research linked to Leprosy. This is the starting point the study compared everyone against.
Source

Questions about rs114231265

What is rs114231265?

rs114231265 is a single position in the genome, in or near the near NTNG1 gene. Published research associates it with leprosy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114231265 linked to?

On MyGeneLog this position is linked to Leprosy. The research behind each link, and its sources, are set out on that condition page.

Does having rs114231265 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114231265 come from?

GWAS Catalog, PLoS pathogens 2022, PMID:36121873. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Leprosy (rs114231265). MyGeneLog™. https://www.mygenelog.com/variants/rs114231265

← See all variants