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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,055 African American or Afro-Caribbean cases, 120,313 African American or Afro-Caribbean controls, 10,664 European ancestry cases, 438,177 European ancestry controls, 554 Hispanic or Latin American cases, 59,108 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 1.6 lower (95% confidence interval 1.52-1.68); p = 4 × 10−11.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 8, band 8q13.3 — between genes, 28.5 kb from RN7SL675P.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Malignant neoplasm of bladder (PheCode 189.21) — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Malignant neoplasm of bladder (PheCode 189.21).
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Malignant neoplasm of bladder (PheCode 189.21) compared to the general population.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs114190422
What is rs114190422?
rs114190422 is a single position in the genome, in or near the near RN7SL675P gene. Published research associates it with malignant neoplasm of bladder (phecode 189.21). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs114190422 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs114190422 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Malignant neoplasm of bladder (PheCode 189.21) (rs114190422). MyGeneLog™. https://www.mygenelog.com/variants/rs114190422