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Psoriasis

near USP8P1 · rs114164395

Where this position leads

Condition: Psoriasis

rs114164395 Condition: Psoriasis Psoriasis Condition rs114164395 rs114164395 near USP8P1

What the study found

Who was studied 394,626 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.801 lower (95% confidence interval 0.62-0.98); p = 3 × 10−42.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 1 kb from USP8P1.

What each result means

A/A No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs114164395

What is rs114164395?

rs114164395 is a single position in the genome, in or near the near USP8P1 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114164395 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs114164395 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114164395 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs114164395). MyGeneLog™. https://www.mygenelog.com/variants/rs114164395

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