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Attention deficit hyperactivity disorder

VGLL3 · rs114142727

Where this position leads

Condition: ADHD (Attention Deficit Hyperactivity Disorder)

rs114142727 Condition: ADHD (Attention Deficit Hyperactivity Disorder) ADHD (Attention Deficit Hyperactivi… Condition rs114142727 rs114142727 VGLL3

What the study found

Who was studied 38,691 European ancestry cases, 186,843 European ancestry controls.

The effect Each copy of the C allele carried 1.28 times the odds of Attention deficit hyperactivity disorder (95% confidence interval 1.21-1.36); p = 5 × 10−10.

How common The C allele had a frequency of about 99% in the people studied.

Where it sits Chromosome 3, band 3p12.1 — in an intron of VGLL3.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Attention deficit hyperactivity disorder compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Attention deficit hyperactivity disorder.
G/G Published research associates this genotype with typical/baseline likelihood of Attention deficit hyperactivity disorder — no copies of the reported risk allele.
Source
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Demontis D, Walters GB, Athanasiadis G, Walters R, Therrien K, Nielsen TT, Farajzadeh L, Voloudakis G, Bendl J, Zeng B, Zhang W, Grove J
and 35 more — show all
Als TD, Duan J, Satterstrom FK, Bybjerg-Grauholm J, Bækved-Hansen M, Gudmundsson OO, Magnusson SH, Baldursson G, Davidsdottir K, Haraldsdottir GS, Agerbo E, Hoffman GE, Dalsgaard S, Martin J, Ribasés M, Boomsma DI, Soler Artigas M, Roth Mota N, Howrigan D, Medland SE, Zayats T, Rajagopal VM, Nordentoft M, Mors O, Hougaard DM, Mortensen PB, Daly MJ, Faraone SV, Stefansson H, Roussos P, Franke B, Werge T, Neale BM, Stefansson K, Børglum AD
ADHD Working Group of the Psychiatric Genomics Consortium · iPSYCH-Broad Consortium
Nature genetics · 2023 · PMID 36702997

Questions about rs114142727

What is rs114142727?

rs114142727 is a single position in the genome, in or near the VGLL3 gene. Published research associates it with attention deficit hyperactivity disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs114142727 linked to?

On MyGeneLog this position is linked to ADHD (Attention Deficit Hyperactivity Disorder). The research behind each link, and its sources, are set out on that condition page.

Does having rs114142727 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114142727 come from?

GWAS Catalog, Nature genetics 2023, PMID:36702997. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Attention deficit hyperactivity disorder (rs114142727). MyGeneLog™. https://www.mygenelog.com/variants/rs114142727

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