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Triglyceride levels

COL18A1 · rs114139997

What the study found

Who was studied 99,432 Admixed African or African ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.264 lower (95% confidence interval 0.23-0.3); p = 5 × 10−49.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 21, band 21q22.3 — a missense change in COL18A1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Triglyceride levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Triglyceride levels.
G/G Published research associates this genotype with typical/baseline likelihood of Triglyceride levels — no copies of the reported risk allele.
Source

Questions about rs114139997

What is rs114139997?

rs114139997 is a single position in the genome, in or near the COL18A1 gene. Published research associates it with triglyceride levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs114139997 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs114139997 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Triglyceride levels (rs114139997). MyGeneLog™. https://www.mygenelog.com/variants/rs114139997

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