Venous thromboembolism recurrence in provoked as first VTE
PRKG1 · rs113846542
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Who was studied 772 European ancestry cases, 2,142 European ancestry controls.
The effect
Each copy of the T allele carried 3.65 times the odds of Venous thromboembolism recurrence in provoked as first VTE (95% confidence interval 2.485384-5.354646); p = 4 × 10−11.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 10, band 10q21.1 — in an intron of PRKG1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Venous thromboembolism recurrence in provoked as first VTE — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Venous thromboembolism recurrence in provoked as first VTE.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Venous thromboembolism recurrence in provoked as first VTE compared to the general population.
rs113846542 is a single position in the genome, in or near the PRKG1 gene. Published research associates it with venous thromboembolism recurrence in provoked as first vte. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs113846542 linked to?
On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.
Does having rs113846542 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs113846542 come from?
GWAS Catalog, Blood 2025, PMID:40811855. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Venous thromboembolism recurrence in provoked as first VTE (rs113846542). MyGeneLog™. https://www.mygenelog.com/variants/rs113846542