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Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B levels

MGAT4B · rs113756550

What the study found

Who was studied 10,708 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 1.26 lower (95% confidence interval 1.18-1.35); p = 2 × 10−198.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 5, band 5q35.3 — a missense change in MGAT4B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B levels.
G/G Published research associates this genotype with typical/baseline likelihood of Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B levels — no copies of the reported risk allele.
Source

Questions about rs113756550

What is rs113756550?

rs113756550 is a single position in the genome, in or near the MGAT4B gene. Published research associates it with alpha-1,3-mannosyl-glycoprotein 4-beta-n-acetylglucosaminyltransferase b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs113756550 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs113756550 come from?

GWAS Catalog, Science (New York, N.Y.) 2021, PMID:34648354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B levels (rs113756550). MyGeneLog™. https://www.mygenelog.com/variants/rs113756550

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