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Acute insulin response (insulin secretion adjusted)

GPSM1 · rs1135314

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,346 Hispanic individuals, 2,087 European ancestry individuals, 332 Pima Indian ancestry individuals; replicated in 741 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.126 lower (95% confidence interval 0.081-0.171); p = 4 × 10−8.

How common The A allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 9, band 9q34.3 — in the 3′ untranslated region of CARD9.

What ClinVar records

Classification Benign for Predisposition to invasive fungal disease due to CARD9 deficiency; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2024-01-24. ClinVar record 365828 NM_052813.5(CARD9):c.*292T>C

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Acute insulin response (insulin secretion adjusted) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Acute insulin response (insulin secretion adjusted).
G/G Published research associates this genotype with typical/baseline likelihood of Acute insulin response (insulin secretion adjusted) — no copies of the reported risk allele.
Source
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Stančáková A, Boomsma DI
and 40 more — show all
de Geus EJC, Eekhoff EMW, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, van Haeften TW, Mahajan A, Boehnke M, Bergman RN, Tuomilehto J, Collins FS, Mohlke KL, Banasik K, Groves CJ, McCarthy MI, Pearson ER, Natali A, Mari A, Buchanan TA, Taylor KD, Xiang AH, Xiang AH, Gjesing AP, Grarup N, Eiberg H, Pedersen O, Chen YD, Laakso M, Norris JM, Smith U, Wagenknecht LE, Baier L, Bowden DW, Hansen T, Walker M, Watanabe RM, 't Hart LM, Hanson RL, Frayling TM
Diabetes Research on Patient Stratification (DIRECT)
Diabetes · 2017 · PMID 28490609 · open access

Questions about rs1135314

What is rs1135314?

rs1135314 is a single position in the genome, in or near the GPSM1 gene. Published research associates it with acute insulin response (insulin secretion adjusted). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1135314 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1135314 come from?

GWAS Catalog, Diabetes 2017, PMID:28490609. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Acute insulin response (insulin secretion adjusted) (rs1135314). MyGeneLog™. https://www.mygenelog.com/variants/rs1135314

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