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Cardiometabolic and hematological traits

RASSF3 · rs113373353

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 35,981 European ancestry individuals; replicated in up to 102,505 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.055 higher (95% confidence interval 0.043-0.067); p = 2 × 10−17.

Where it sits Chromosome 12, band 12q14.2 — in an intron of RASSF3.

What each result means

C/C No copy of the version the research linked to Cardiometabolic and hematological traits. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cardiometabolic and hematological traits. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cardiometabolic and hematological traits. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, Walter K, Min JL, Chen L, Astle W, Cocca M, Deelen P, Elding H
and 55 more — show all
Farmaki AE, Franklin CS, Franberg M, Gaunt TR, Hofman A, Jiang T, Kleber ME, Lachance G, Luan J, Malerba G, Matchan A, Mead D, Memari Y, Ntalla I, Panoutsopoulou K, Pazoki R, Perry JRB, Rivadeneira F, Sabater-Lleal M, Sennblad B, Shin SY, Southam L, Traglia M, van Dijk F, van Leeuwen EM, Zaza G, Zhang W, Amin N, Butterworth A, Chambers JC, Dedoussis G, Dehghan A, Franco OH, Franke L, Frontini M, Gambaro G, Gasparini P, Hamsten A, Issacs A, Kooner JS, Kooperberg C, Langenberg C, Marz W, Scott RA, Swertz MA, Toniolo D, Uitterlinden AG, van Duijn CM, Watkins H, Zeggini E, Maurano MT, Timpson NJ, Reiner AP, Auer PL, Soranzo N
UK10K Consortium
Nature genetics · 2016 · PMID 27668658

Questions about rs113373353

What is rs113373353?

rs113373353 is a single position in the genome, in or near the RASSF3 gene. Published research associates it with cardiometabolic and hematological traits. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs113373353 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs113373353 come from?

GWAS Catalog, Nature genetics 2016, PMID:27668658. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cardiometabolic and hematological traits (rs113373353). MyGeneLog™. https://www.mygenelog.com/variants/rs113373353

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