D2HGDH · rs113372064
Where this position leads
Condition: Chronic Rhinosinusitis with Nasal Polyps
What the study found
Who was studied 9,626 European ancestry cases, 685,602 European ancestry controls.
The effect Each copy of the T allele carried 1.18 times the odds of Chronic rhinosinusitis with nasal polyposis (95% confidence interval 1.12-1.249); p = 2 × 10−9.
How common The T allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 2, band 2q37.3 — in the 3′ untranslated region of D2HGDH.
What ClinVar records
Classification
Benign for D-2-hydroxyglutaric aciduria 1; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-01-13.
ClinVar record 335344 NM_152783.5(D2HGDH):c.*661C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs113372064 is a single position in the genome, in or near the D2HGDH gene. Published research associates it with chronic rhinosinusitis with nasal polyposis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Chronic Rhinosinusitis with Nasal Polyps. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:41213931. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Chronic rhinosinusitis with nasal polyposis (rs113372064). MyGeneLog™. https://www.mygenelog.com/variants/rs113372064