Sensitive

Mucositis (moderate to severe) in head and neck cancer treated with radiotherapy

STING1 · rs1131769

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,183 European ancestry individuals; replicated in 597 Dutch ancestry individuals.

The effect Each copy of the C allele carried 1.95 times the odds of Mucositis (moderate to severe) in head and neck cancer treated with radiotherapy (95% confidence interval 1.48-2.41); p = 4 × 10⁻¹⁶.

Where it sits Chromosome 5, band 5q31.2 — a missense change in STING1.

What ClinVar records

Classification Benign for STING-associated vasculopathy with onset in infancy; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 10 submitters), last evaluated 2026-02-04. ClinVar record 403550 NM_198282.4(STING1):c.695A>G (p.His232Arg)

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Two copies of the version the research linked to Mucositis (moderate to severe) in head and neck cancer treated with radiotherapy. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Mucositis (moderate to severe) in head and neck cancer treated with radiotherapy. That is a smaller link than two copies.

T/T No copy of the version the research linked to Mucositis (moderate to severe) in head and neck cancer treated with radiotherapy. This is the starting point the study compared everyone against.

Source

A genome-wide association study of radiotherapy induced toxicity in head and neck cancer patients identifies a susceptibility locus associated with mucositis

Schack LMH, Naderi E, Fachal L, Dorling L, Luccarini C, Dunning AM, Ong EHW, Chua MLK, Langendijk JA, Alizadeh BZ, Overgaard J, Eriksen JG

and 2 more — show all

Andreassen CN, Alsner J

Head and Neck Group of the Radiogenomics Consortium · Danish Head and Neck Cancer Group (DAHANCA)

British journal of cancer · 2022 · PMID 35039627 · open access

Questions about rs1131769

What is rs1131769?

rs1131769 is a single position in the genome, in or near the STING1 gene. Published research associates it with mucositis (moderate to severe) in head and neck cancer treated with radiotherapy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1131769 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1131769 come from?

GWAS Catalog, British journal of cancer 2022, PMID:35039627. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Mucositis (moderate to severe) in head and neck cancer treated with radiotherapy (rs1131769). MyGeneLog™. https://www.mygenelog.com/variants/rs1131769

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