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Vitamin B12 levels

TCN2 · rs1131603

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 38,229 Danish, Icelandic ancestry individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 5 × 10⁻⁴⁹.

How common The C allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 22, band 22q12.2 — a missense change in TCN2.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vitamin B12 levels compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vitamin B12 levels.

T/T Published research associates this genotype with typical/baseline likelihood of Vitamin B12 levels — no copies of the reported risk allele.

Source

Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets

Grarup N, Sulem P, Sandholt CH, Thorleifsson G, Ahluwalia TS, Steinthorsdottir V, Bjarnason H, Gudbjartsson DF, Magnusson OT, Sparsø T, Albrechtsen A, Kong A

and 19 more — show all

Masson G, Tian G, Cao H, Nie C, Kristiansen K, Husemoen LL, Thuesen B, Li Y, Nielsen R, Linneberg A, Olafsson I, Eyjolfsson GI, Jørgensen T, Wang J, Wang J, Hansen T, Thorsteinsdottir U, Stefánsson K, Pedersen O

PLoS genetics · 2013 · PMID 23754956 · open access

Questions about rs1131603

What is rs1131603?

rs1131603 is a single position in the genome, in or near the TCN2 gene. Published research associates it with vitamin b12 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1131603 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1131603 come from?

GWAS Catalog, PLoS genetics 2013, PMID:23754956. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Vitamin B12 levels (rs1131603). MyGeneLog™. https://www.mygenelog.com/variants/rs1131603

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