Standard

Platelet-to-lymphocyte ratio

CDC37L1 · rs113018536

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 234,552 European ancestry individuals; replicated in 100,478 European ancestry individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 4 × 10⁻¹¹.

How common The C allele had a frequency of about 94% in the people studied.

Where it sits Chromosome 9, band 9p24.1 — in an intron of CDC37L1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Platelet-to-lymphocyte ratio compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Platelet-to-lymphocyte ratio.

T/T Published research associates this genotype with typical/baseline likelihood of Platelet-to-lymphocyte ratio — no copies of the reported risk allele.

Source

Genetic determinants of blood-cell traits influence susceptibility to childhood acute lymphoblastic leukemia

Kachuri L, Jeon S, DeWan AT, Metayer C, Ma X, Witte JS, Chiang CWK, Wiemels JL, de Smith AJ

American journal of human genetics · 2021 · PMID 34469753

Questions about rs113018536

What is rs113018536?

rs113018536 is a single position in the genome, in or near the CDC37L1 gene. Published research associates it with platelet-to-lymphocyte ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs113018536 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs113018536 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Platelet-to-lymphocyte ratio (rs113018536). MyGeneLog™. https://www.mygenelog.com/variants/rs113018536

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