Standard
Post bronchodilator FEV1/FVC ratio
near MGMT · rs112905267
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Post bronchodilator FEV1/FVC ratio compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Post bronchodilator FEV1/FVC ratio.
G/G
Published research associates this genotype with typical/baseline likelihood of Post bronchodilator FEV1/FVC ratio — no copies of the reported risk allele.
Source
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Lutz SM,
Cho MH,
Young K,
Hersh CP,
Castaldi PJ,
McDonald ML,
Regan E,
Mattheisen M,
DeMeo DL,
Parker M,
Foreman M,
Make BJ
and 12 more — show all
Jensen RL,
Casaburi R,
Lomas DA,
Bhatt SP,
Bakke P,
Gulsvik A,
Crapo JD,
Beaty TH,
Laird NM,
Lange C,
Hokanson JE,
Silverman EK
BMC genetics · 2015 · PMID 26634245 · open access
Questions about rs112905267
What is rs112905267?
rs112905267 is a single position in the genome, in or near the near MGMT gene. Published research associates it with post bronchodilator fev1/fvc ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112905267 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112905267 come from?
GWAS Catalog, BMC Genet 2015, PMID:26634245. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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