Standard
Soluble transferrin receptor concentration
TFRC · rs112856048
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 45,330 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.1 lower (95% confidence interval 0.085-0.115); p = 6 × 10−38.
How common The A allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 3, band 3q29 — in an intron of TFRC.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Soluble transferrin receptor concentration compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Soluble transferrin receptor concentration.
G/G
Published research associates this genotype with typical/baseline likelihood of Soluble transferrin receptor concentration — no copies of the reported risk allele.
Source
Novel loci and biomedical consequences of iron homoeostasis variation
Allara E,
Bell S,
Smith R,
Keene SJ,
Gill D,
Gaziano L,
Morselli Gysi D,
Wang F,
Tragante V,
Mason A,
Karthikeyan S,
Lumbers RT
and 60 more — show all
Bonglack E,
Ouwehand W,
Roberts DJ,
Dowsett J,
Ostrowski SR,
Larsen MH,
Ullum H,
Pedersen OB,
Brunak S,
Banasik K,
Erikstrup C,
Mitchell J,
Fuchsberger C,
Pattaro C,
Pramstaller PP,
Girelli D,
Arvas M,
Toivonen J,
Molnos S,
Peters A,
Polasek O,
Rudan I,
Hayward C,
McDonnell C,
Pirastu N,
Wilson JF,
van den Hurk K,
Quee F,
Ferrucci L,
Bandinelli S,
Tanaka T,
Girotto G,
Concas MP,
Pecori A,
Verweij N,
van der Harst P,
van de Vegte YJ,
Kiemeney LA,
Sweep FC,
Galesloot TE,
Sulem P,
Gudbjartsson D,
Ferkingstad E,
Djousse L,
Cho K,
Inouye M,
Burgess S,
Benyamin B,
Oexle K,
Swinkels D,
Stefansson K,
Magnusson M,
Ganna A,
Gaziano M,
Ivey K,
Danesh J,
Pereira A,
Wood AM,
Butterworth AS,
Di Angelantonio E
Communications biology · 2024 · PMID 39643614 · open access
Questions about rs112856048
What is rs112856048?
rs112856048 is a single position in the genome, in or near the TFRC gene. Published research associates it with soluble transferrin receptor concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112856048 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112856048 come from?
GWAS Catalog, Communications biology 2024, PMID:39643614. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Soluble transferrin receptor concentration (rs112856048). MyGeneLog™. https://www.mygenelog.com/variants/rs112856048
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