G/GPublished research associates this genotype with typical/baseline likelihood of Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) — no copies of the reported risk allele. (GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655)
G/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies). (GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655)
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) compared to the general population. (GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655)
Annals of the rheumatic diseases · 2019 · PMID 30573655
Questions about rs112846137
What is rs112846137?
rs112846137 is a single position in the genome, in or near the KPNA4-ARL14 gene. Published research associates it with systemic seropositive rheumatic diseases (systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs112846137 linked to?
On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.
Does having rs112846137 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112846137 come from?
GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.