Gene Knowledge Graph
UTC
Sensitive

Skin cancer

ZFHX4-AS1 · rs112840089

Where this position leads

Condition: Sun Sensitivity, Freckling and Skin Cancer Risk

rs112840089 Condition: Sun Sensitivity, Freckling and Skin Cancer Risk Sun Sensitivity, Freckling and Skin… Condition rs112840089 rs112840089 ZFHX4-AS1

What the study found

Who was studied 431 African American or Afro-Caribbean cases, 55,074 African American or Afro-Caribbean controls, 55,282 European ancestry cases, 260,386 European ancestry controls, 979 Hispanic or Latin American cases, 28,335 Hispanic or Latin American controls.

The effect Each copy of the T allele shifted the measure 0.123 higher (95% confidence interval 0.087-0.158); p = 7 × 10−14.

How common The T allele had a frequency of about 94% in the people studied.

Where it sits Chromosome 8, band 8q21.13 — in an intron of ZFHX4-AS1.

What each result means

C/C No copy of the version the research linked to Skin cancer. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Skin cancer. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Skin cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs112840089

What is rs112840089?

rs112840089 is a single position in the genome, in or near the ZFHX4-AS1 gene. Published research associates it with skin cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs112840089 linked to?

On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.

Does having rs112840089 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112840089 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Skin cancer (rs112840089). MyGeneLog™. https://www.mygenelog.com/variants/rs112840089

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