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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 14,183 Icelandic ancestry individuals; replicated in 2,146 Swedish ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.13 SD units higher; p = 2 × 10−11.
How common The A allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 14, band 14q32.33 — between genes, 0.7 kb from IGHA1.
What each result means
A/ATwo copies of the version the research linked to Composite immunoglobulin trait (IgA/IgM). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Composite immunoglobulin trait (IgA/IgM). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Composite immunoglobulin trait (IgA/IgM). This is the starting point the study compared everyone against.
rs112763553 is a single position in the genome, in or near the IGHA1 gene. Published research associates it with composite immunoglobulin trait (iga/igm). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112763553 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112763553 come from?
GWAS Catalog, Nature genetics 2017, PMID:28628107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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