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Who was studied 380,287 European ancestry individuals; replicated in 4,089 European ancestry cases, 11,901 European ancestry controls, 44,848 cases, 1,571,864 controls.
The effect
Each copy of the A allele shifted the measure 0.0859 lower (95% confidence interval 0.064-0.108); p = 2 × 10−14.
How common The A allele had a frequency of about 91% in the people studied.
Where it sits Chromosome 12, band 12q24.21 — in an intron of MED13L.
What each result means
A/ATwo copies of the version the research linked to Cutaneous melanoma (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cutaneous melanoma (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cutaneous melanoma (MTAG). This is the starting point the study compared everyone against.
The Journal of investigative dermatology · 2022 · PMID 34813871
Questions about rs112761681
What is rs112761681?
rs112761681 is a single position in the genome, in or near the MED13L gene. Published research associates it with cutaneous melanoma (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs112761681 linked to?
On MyGeneLog this position is linked to Cutaneous Malignant Melanoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs112761681 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112761681 come from?
GWAS Catalog, The Journal of investigative dermatology 2022, PMID:34813871. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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