Other non-epithelial cancer of skin (PheCode 172.2)
CTNNA2 · rs112716246
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Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
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What the study found
Who was studied 709 African American or Afro-Caribbean cases, 120,241 African American or Afro-Caribbean controls, 68,143 European ancestry cases, 360,898 European ancestry controls, 1,847 Hispanic or Latin American cases, 57,159 Hispanic or Latin American controls.
The effect
Each copy of the A allele shifted the measure 1.69 lower (95% confidence interval 1.61-1.76); p = 4 × 10−11.
How common The A allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 2, band 2p12 — inside CTNNA2.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Other non-epithelial cancer of skin (PheCode 172.2) compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Other non-epithelial cancer of skin (PheCode 172.2).
G/GPublished research associates this genotype with typical/baseline likelihood of Other non-epithelial cancer of skin (PheCode 172.2) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs112716246
What is rs112716246?
rs112716246 is a single position in the genome, in or near the CTNNA2 gene. Published research associates it with other non-epithelial cancer of skin (phecode 172.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112716246 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112716246 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Other non-epithelial cancer of skin (PheCode 172.2) (rs112716246). MyGeneLog™. https://www.mygenelog.com/variants/rs112716246