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Sunburns

TYR · rs1126809

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 9,283 European ancestry individuals; replicated in 4,236 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.6 higher (95% confidence interval 0.38-0.82); p = 2 × 10⁻⁸.

Where it sits Chromosome 11, band 11q14.3 — a missense change in TYR.

What ClinVar records

Classification Conflicting classifications of pathogenicity; other for Oculocutaneous albinism type 1B, Temperature-sensitive oculocutaneous albinism type 1, Melanoma, cutaneous malignant, susceptibility to, 8, SKIN/HAIR/EYE PIGMENTATION 3, LIGHT/DARK SKIN, Skin/hair/eye pigmentation 3, blue/green eyes and 7 more; criteria provided, conflicting classifications (1 of 4 stars, 24 submitters), last evaluated 2026-06-01. ClinVar record 3779 NM_000372.5(TYR):c.1205G>A (p.Arg402Gln)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version the research linked to Sunburns. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Sunburns. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Sunburns. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans

Zhang M, Song F, Liang L, Nan H, Zhang J, Liu H, Wang LE, Wei Q, Lee JE, Amos CI, Kraft P, Qureshi AA

and 1 more — show all

Han J

Human molecular genetics · 2013 · PMID 23548203

What people read about alongside this

Skin, sun and hair5 Short-sightedness and screens4

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1126809

What is rs1126809?

rs1126809 is a single position in the genome, in or near the TYR gene. Published research associates it with sunburns. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs1126809?

Subjects that appear in the title or abstract of the same papers as this rsID include skin, sun and hair (5 papers), short-sightedness and screens (4 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1126809 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1126809 come from?

GWAS Catalog, Hum Mol Genet 2013, PMID:23548203. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Sunburns (rs1126809). MyGeneLog™. https://www.mygenelog.com/variants/rs1126809

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