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Interleukin-6 levels

IL6R · rs11265618

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 52,654 European ancestry individuals; replicated in 14,774 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0473 lower (95% confidence interval 0.036-0.059); p = 3 × 10⁻¹⁹.

How common The T allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 1, band 1q21.3 — in an intron of IL6R.

What each result means

C/C No copy of the version the research linked to Interleukin-6 levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Interleukin-6 levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Interleukin-6 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, Bis JC, Mitchell BD

and 114 more — show all

de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater-Lleal M, Naderi E, Seppälä I, Shah T, Singhal G, Standl M, Teumer A, Thalamuthu A, Thiering E, Trompet S, Ballantyne CM, Benjamin EJ, Casas JP, Toben C, Dedoussis G, Deelen J, Durda P, Engmann J, Feitosa MF, Grallert H, Hammarstedt A, Harris SE, Homuth G, Hottenga JJ, Jalkanen S, Jamshidi Y, Jawahar MC, Jess T, Kivimaki M, Kleber ME, Lahti J, Liu Y, Marques-Vidal P, Mellström D, Mooijaart SP, Müller-Nurasyid M, Penninx B, Revez JA, Rossing P, Räikkönen K, Sattar N, Scharnagl H, Sennblad B, Silveira A, Pourcain BS, Timpson NJ, Trollor J, van Dongen J, Van Heemst D, Visvikis-Siest S, Vollenweider P, Völker U, Waldenberger M, Willemsen G, Zabaneh D, Morris RW, Arnett DK, Baune BT, Boomsma DI, Chang YC, Deary IJ, Deloukas P, Eriksson JG, Evans DM, Ferreira MA, Gaunt T, Gudnason V, Hamsten A, Heinrich J, Hingorani A, Humphries SE, Jukema JW, Koenig W, Kumari M, Kutalik Z, Lawlor DA, Lehtimäki T, März W, Mather KA, Naitza S, Nauck M, Ohlsson C, Price JF, Raitakari O, Rice K, Sachdev PS, Slagboom E, Sørensen TIA, Spector T, Stacey D, Stathopoulou MG, Tanaka T, Wannamethee SG, Whincup P, Rotter JI, Dehghan A, Boerwinkle E, Psaty BM, Snieder H, Alizadeh BZ

CHARGE Inflammation Working Group

Human molecular genetics · 2021 · PMID 33517400 · open access

Questions about rs11265618

What is rs11265618?

rs11265618 is a single position in the genome, in or near the IL6R gene. Published research associates it with interleukin-6 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11265618 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11265618 come from?

GWAS Catalog, Human molecular genetics 2021, PMID:33517400. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Interleukin-6 levels (rs11265618). MyGeneLog™. https://www.mygenelog.com/variants/rs11265618

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