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Who was studied 2,215 Western European ancestry cases, 8,566 Western European ancestry controls; replicated in 2,844 European ancestry cases, 7,270 European ancestry controls.
The effect
Each copy of the C allele carried 1.53 times the odds of Renal cell carcinoma (95% confidence interval 1.39-1.67); p = 1 × 10−9.
Where it sits Chromosome 11, band 11q13.3 — between genes, 2.3 kb from LINC02953.
What each result means
C/CTwo copies of the version the research linked to Renal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Renal cell carcinoma. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Renal cell carcinoma. This is the starting point the study compared everyone against.
rs11263654 is a single position in the genome, in or near the AX746803 gene. Published research associates it with renal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11263654 linked to?
On MyGeneLog this position is linked to Renal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs11263654 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11263654 come from?
GWAS Catalog, PloS one 2015, PMID:25826619. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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