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Melanoma

near CBFA2T3 · rs112584165

Where this position leads

Condition: Cutaneous Malignant Melanoma

rs112584165 Condition: Cutaneous Malignant Melanoma Cutaneous Malignant Melanoma Condition rs112584165 rs112584165 near CBFA2T3

What the study found

Who was studied 6,777 European ancestry cases, 410,350 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 8 × 10−9.

Where it sits Chromosome 16, band 16q24.3 — between genes, 42.1 kb from CBFA2T3.

What each result means

A/A Two copies of the version the research linked to Melanoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Melanoma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Melanoma. This is the starting point the study compared everyone against.
Source
Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts
Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH
and 7 more — show all
Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, Sakoda LC, Witte JS
Nature communications · 2020 · PMID 32887889 · open access

Questions about rs112584165

What is rs112584165?

rs112584165 is a single position in the genome, in or near the near CBFA2T3 gene. Published research associates it with melanoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs112584165 linked to?

On MyGeneLog this position is linked to Cutaneous Malignant Melanoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs112584165 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112584165 come from?

GWAS Catalog, Nature communications 2020, PMID:32887889. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Melanoma (rs112584165). MyGeneLog™. https://www.mygenelog.com/variants/rs112584165

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