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HVEM on naive CD8+ T cell

POLR1HASP · rs112580141

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,247 Sardinian (founder/genetic isolate) ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.262 higher (95% confidence interval 0.17-0.35); p = 2 × 10⁻⁸.

How common The C allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — inside POLR1HASP.

What each result means

C/C Two copies of the version the research linked to HVEM on naive CD8+ T cell. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to HVEM on naive CD8+ T cell. That is a smaller link than two copies.

T/T No copy of the version the research linked to HVEM on naive CD8+ T cell. This is the starting point the study compared everyone against.

Source

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG

and 16 more — show all

Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F

Nature genetics · 2020 · PMID 32929287

Questions about rs112580141

What is rs112580141?

rs112580141 is a single position in the genome, in or near the POLR1HASP gene. Published research associates it with hvem on naive cd8+ t cell. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs112580141 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112580141 come from?

GWAS Catalog, Nature genetics 2020, PMID:32929287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

HVEM on naive CD8+ T cell (rs112580141). MyGeneLog™. https://www.mygenelog.com/variants/rs112580141

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