C/CPublished research associates this genotype with typical/baseline likelihood of Alzheimer's disease in APOE e4- carriers — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alzheimer's disease in APOE e4- carriers.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alzheimer's disease in APOE e4- carriers compared to the general population.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017 · PMID 28183528
Questions about rs11257238
What is rs11257238?
rs11257238 is a single position in the genome, in or near the near USP6NL gene. Published research associates it with alzheimer's disease in apoe e4- carriers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11257238 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs11257238 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11257238 come from?
GWAS Catalog, Alzheimers Dement 2017, PMID:28183528. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.