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Its strongest genetic-study result is p = 10−58, with 6 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 7,577 European ancestry cases, 9,979 European ancestry controls.
The effect
Each copy of the T allele carried 1.18 times the odds of Colorectal cancer; p = 4 × 10−13.
How common The T allele had a frequency of about 68% in the people studied.
Where it sits Chromosome 10, band 10p14 — between genes, 27.8 kb from LOC105376400.
How common each version is
AT
KoreanKRGDB
A 35.6% · T 64.4%
KoreanKorea4K
A 34.7% · T 65.3%
KoreanKorea1K
A 34.6% · T 65.4%
Japanese ToMMo
A 36.7% · T 63.3%
World gnomAD
A 25.5% · T 74.5%
World 1000 Genomes
A 24.7% · T 75.3%
World TOPMed
A 25.1% · T 74.9%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ANo copy of the version the research linked to Colorectal cancer. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Colorectal cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Scientific reports · 2015 · PMID 25990418 · open access
Questions about rs11255841
What is rs11255841?
rs11255841 is a single position in the genome, in or near the GATA3 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11255841 linked to?
On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs11255841 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11255841 come from?
GWAS Catalog, Sci Rep 2015, PMID:25990418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Colorectal cancer (rs11255841). MyGeneLog™. https://www.mygenelog.com/variants/rs11255841