Gene Knowledge Graph UTC
Sensitive

Colorectal cancer

GATA3 · rs11255841

Where this position leads

Condition: Colorectal Cancer

rs11255841 Condition: Colorectal Cancer Colorectal Cancer Condition rs11255841 rs11255841 GATA3

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Colorectal cancer — no copies of the reported risk allele. (GWAS Catalog, Sci Rep 2015, PMID:25990418)
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Colorectal cancer. (GWAS Catalog, Sci Rep 2015, PMID:25990418)
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Colorectal cancer compared to the general population. (GWAS Catalog, Sci Rep 2015, PMID:25990418)
Source
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer
Al-Tassan NA, Whiffin N, Hosking FJ, Palles C, Farrington SM, Dobbins SE, Harris R, Gorman M, Tenesa A, Meyer BF, Wakil SM, Kinnersley B
and 23 more — show all
Campbell H, Martin L, Smith CG, Idziaszczyk S, Barclay E, Maughan TS, Kaplan R, Kerr R, Kerr D, Buchanan DD, Win AK, Hopper J, Jenkins M, Lindor NM, Newcomb PA, Gallinger S, Conti D, Schumacher F, Casey G, Dunlop MG, Tomlinson IP, Cheadle JP, Houlston RS
Scientific reports · 2015 · PMID 25990418 · open access

Questions about rs11255841

What is rs11255841?

rs11255841 is a single position in the genome, in or near the GATA3 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11255841 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs11255841 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11255841 come from?

GWAS Catalog, Sci Rep 2015, PMID:25990418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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