Gene Knowledge Graph
Gene Knowledge Graph UTC
Sensitive

Schizophrenia

LETM2 · rs112537273

Where this position leads

Condition: Schizophrenia

rs112537273 Condition: Schizophrenia Schizophrenia Condition rs112537273 rs112537273 LETM2

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
Source
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect
Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T
and 20 more — show all
Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N
Schizophrenia bulletin · 2019 · PMID 30285260

Questions about rs112537273

What is rs112537273?

rs112537273 is a single position in the genome, in or near the LETM2 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs112537273 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs112537273 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112537273 come from?

GWAS Catalog, Schizophr Bull 2018, PMID:30285260. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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