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HIV setpoint viral load

HLA-B · rs112515516

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs112515516 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs112515516 rs112515516 HLA-B

What the study found

Who was studied 7,890 European and African ancestry males.

The effect Each copy of the A allele shifted the measure 0.86 lower (95% confidence interval 0.78-0.94); p = 6 × 10−107.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of HIV setpoint viral load compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with HIV setpoint viral load.
G/G Published research associates this genotype with typical/baseline likelihood of HIV setpoint viral load — no copies of the reported risk allele.
Source
Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH
Vergara C, Tuff JF, Fellay J, Duggal P, Scully EP, McLaren PJ
International Collaboration for the Genomics of HIV (ICGH)
JCI insight · 2023 · PMID 37097752 · open access

Questions about rs112515516

What is rs112515516?

rs112515516 is a single position in the genome, in or near the HLA-B gene. Published research associates it with hiv setpoint viral load. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs112515516 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs112515516 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs112515516 come from?

GWAS Catalog, JCI insight 2023, PMID:37097752. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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HIV setpoint viral load (rs112515516). MyGeneLog™. https://www.mygenelog.com/variants/rs112515516

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