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Who was studied 20,406 European ancestry cases, 223,918 European ancestry controls; replicated in 15,068 European ancestry cases, 43,587 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.128 higher (95% confidence interval 0.089-0.168); p = 3 × 10−10.
How common The T allele had a frequency of about 96% in the people studied.
Where it sits Chromosome 11, band 11p15.5 — in an intron of RIC8A.
What each result means
G/GNo copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 31649266 · open access
Questions about rs11246003
What is rs11246003?
rs11246003 is a single position in the genome, in or near the RIC8A gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11246003 linked to?
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
Does having rs11246003 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11246003 come from?
GWAS Catalog, Nature communications 2019, PMID:31649266. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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